COEHP Directory

Tyrone Washington

Tyrone Washington

Assistant Professor

College of Education and Health Professions

(HHPR)-Health, Human Performance, & Recreation

Phone: 479-575-6693

Fax: (479) 575-5778

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Dr. Washington is married to Lynette Keppeler Washington. They have four children, Jeremiah Aaron, Maiesha Rae, Lydia Amaru, and Chloe Lucille.

Dr. Washington's research laboratory employs molecular biology techniques with in vivo and in vitro  models examining muscle plasticity. Currently Dr. Washingon's laboratory is examining cellular signlaing within skeletal muscle induced by aging, obesity, cancer cachexia, regeneration, or altered loading.

Exercise Physiology

Ph.D., Exercise Science, University of South Carolina, 2008
B.S., Biological Science, University of South Carolina, 2000

Publications

  1. Greene NP, Brown JL, Rosa-Caldwell ME, Lee De, Blackwell TA, Washington TA. (2017). Curr Diabetes Rev 2016 (Epub ahead of print). PMID: 27875947
  2. Brown JL, Rosa ME, Lee DE, *Brown LA, *Perry RA, Shimkus KL, Fluckey JD, Carson JA, Dridi S, Washington TA, Grene NP (2016). PCG-1α4 gene expression is suppressed by the IL-6--ERK1/2 MAPK signaling axis and altered by resistance exercise, obesity, and muscle injury. Acta Physiol (Epub ahead of print, 2016). PMID: 27809412
  3. Tucker M, Caldwell A, Butts C, Robinson F, Reynebeau H, Kavouras S, McDermott B, Washington T, Turner R, Ganio M (2016). Effect of hypohydration on thermoregulatory responses in males with low and high body fat exercising in the heat. J Appl Physiol 122 (1): 142-152. PMID: 27789773
  4. Kasukonis B, Kim J, *Brown L, Jones J, Ahmadi S, Washington TA, Wolchok JC (2016). Co-delivery of infusion decellularized skeletal muscle with minced autografts improved recovery from volumetric muscle loss injury in a rat model. Tissue Eng Part A 22 (19-20): 1151-1163. PMID: 27570911  
  5. Baum JI, Smith DS, *Davis G, Washington TA, Shouse SA. (2016). Leucine supplementation at the onset of high-fat feeding does not prevent weight gain or improve glucose regulation in male, Sprague-Dawley rats. J Physiol Biochem 72 (4): 781-789. PMID: 27544228
  6. Rosa M, Lee D, Brown J, *Brown L, *Perry R Jr., Greene E, Carvallo Chaigneau F, Washington T, Greene N. (2016) Moderate physical activity promotes basal hepatic autophagy in diet-induced obese mice. Appl Physiol, Nutr, and Metab (Accepted). PMID: 28084795
  7. Kim JT, Kasukonis B, *Brown LA, Washington TA, Wolchok JC. (2016) Recovery from volumetric muscle loss injury: A comparison between young and aged rats. Exp Gerontol 83: 37-46. PMID: 27435497
  8. Lee DE, Brown JL, Rosa ME, *Brown LA, *Perry RA Jr, Washington TA, Greene NP. (2016) Translational machinery of mitochondrial mRNA promoted by physical activity in Western diet-induced obese mice. Acta Physiol 218 (3):167-177. PMID: 27061106
  9. Kasukonis B, Kin J, Washington T, Wolchok J. (2016) Development of an infusion bioreactor for accelerated preparation of decellularized skeletal muscle scaffolds. Biotechnology Progress 32 (3): 745-55. PMID: 26949076
  10. *Perry RA, *Brown LA, Lee DE, Brown JL, Greene NP, Washington TA. (2016) Differential effects of leucine supplementation at the onset of skeletal muscle regeneration in aging mice. J Mech Ageing Dev 157: 7-16. PMID: 27327351 
  11. *Perry RA, *Brown LA, Lee DE, Brown JL, Greene NP, Washington TA. (2016) The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation during the onset of skeletal muscle regeneration. Data in Brief 8:1426-32. PMID: 27617277
  12. Lee DE, Brown JL, Rosa ME, *Brown LA, *Perry RA, Wiggs MP, Crouse SF, Fluckey JD, Washington TA, Greene NP. (2016) microRNA-16 is downregulated during insulin resistance and controls skeletal muscle protein accretion. J Cell Biochem 117 (8): 1775-87. PMID: 26683117
  13. Greene NP, Lee DE, Brown JL, Rosa ME, *Brown LA, *Perry RA, Henry JN, Washington TA. (2015) Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice. Physiol Reports 3 (7). PMID: 26177961
  14. Tucker MA, Adams JD, *Brown LA, Ridings CB, Burchfield JM, Robinson FB, McDermott JL, Schreiber BA, Moyen NE, Washington TA, Bermudez AC, Bennett MP, Buyckx ME, Ganio MS. (2016) No Change in 24-hour hydration status following a moderate increase in fluid composition. J Am Coll Nutr 35 (4): 308-16. PMID 26595723
  15. *Brown LA, Lee DE, *Patton JP, *Perry RA, Brown JL, Baum JI, Smith-Blair N, Greene NP, Washington TA. (2015) Diet-induced obesity alters anabolic signaling in mice at the onset of muscle regeneration. Acta Physiologica 215 (1): 49-57. PMID: 26052759
  16. Washington TA, Clements JM, Thompson RW, Lowe LL, Carson JA.  (2014) Lactate dehydrogenase regulation in aged skeletal muscle: Regulation by anabolic steroids and functional overload. Exp Gerontol 57: 66-74. PMID: 24835193
  17. Tucker MA, Ganio MA, Adams JD, *Brown LA, Ridings CR, Burchfield J, Robinson B, McDermott J, Moyen NE, Schreiber B, Washington TA, Bermudez A, Bennett M, Buyckx M. (2015) Hydration status over a 24-h period is not affected by ingested beverage composition. J Am Coll Nutr 34 (4): 318-2. PMID: 25789444.
  18. *Glenn JM, Brown B, Edwards A, Galey M, Rickert B, Washington T. (2014) Validity and Reliability of Evaluating and Increasing Abdominal Strength Utilizing Electromyography and Isometric Force Production. J Sci Med Sport 18 (4): 457-62. PMID: 25024133.
  19. Bottje W, Kong B, Song J, Lee J, Hargis B, Lassiter K, Washington T, Baum J, Wing T, Hardiman J. (2014) Potential roles of mTOR and protein degradation pathways in the phenotypic expression of feed efficiency in broilers. J of Biochem and Physiol 3 (1): 125. doi: 10.4172/2168-9652.1000125
  20. Greene NP, Nilsson MI, Washington TA, Lee DE, *Brown LA, *Papineau AM, Shimkus KL, Crouse SF, Fluckey JD. (2014) Impaired exercise-induced mitochondrial biogenesis in the obese zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation. Am J Physiol Endocrinol Metab. 306 (5): E503-11. PMID: 24398401
  21. Washington TA, *Smith DA, Davis G, Baum J, Bottje W. (2013) Monocarboxylate transporter expression at the onset of skeletal muscle regeneration. Physiol Reports 1 (4): 1-11. PMID: 24303150
  22. Washington TA, Davis JM, Wilson LB, Lowe LL, White JP, Carson JA. (2011) Skeletal muscle mass recovery from atrophy in IL-6 knockout mice.  Acta Physiologica 202: 657-669. PMID: 21418148 
  23. James P. White, James M. Reecy, Tyrone A. Washington, Shuichi Sato, Michael E. Le, J. Mark Davis, L. Britt Wilson, and James A. Carson. (2009) Overload-induced skeletal muscle extracellular matrix remodeling and myofiber growth in mice lacking IL-6.  Acta Physiologica 197 (4): 321-332. PMID: 19681796   
  24. Washington TA, Reecy JM, Thompson RW, Lowe LL, McClung JM, and Carson JA. (2004) Lactate dehydrogenase expression at the onset of altered loading in rat soleus muscle. J Appl Physiol 97: 1424-1430. PMID: 15358753

Dr. Washington is an assistant professor in exercise science. He received his Ph.D. from the University of South Carolina under the mentorship of Dr. James Carson in his Integrative Muscle Biology Laboratory. Dr. Washington while at the University of South Carolina worked on various projects that included skeletal muscle hypertrophy, skeletal muscle atrophy, skeletal muscle regeneration, and cancer cachexia. Dr. Washington's doctoral work focused on the role of Interleukin-6 during skeletal muscle hypertrophy and recovery from disuse atrophy. Previously, Dr. Washington taught Anatomy and Physiology I and II, and he oversaw the Anatomy and Physiology labs at the University of Evansville in Indiana.

NIH/NIAMS – Pilot and feasibility clinical research grants in arthritis and musculoskeletal and skin diseases (R21), 2012. o Research Project; “The role of systemic and intramuscular markers to identify pain and influence clinical outcomes of low back pain patients.” Role: Principal Investigator (Submitted: $365,242)

NIH/NIA - Claude Pepper Older Americans Independence Center (OAIC) Pilot Study Grant, 2012 o Research Project: “The Effect of Leucine Supplementation on Aged Skeletal Muscle Regenerative Capacity.” Role: Principal Investigator (Funded: $20,000)

Student Undergraduate Research Fellowship Grant, 2012 o Research Project: “The effect of obesity of cell cycle regulation during skeletal muscle regeneration.” Role: Principal Investigator ($2750); awarded to Jillian Patton

American Biosciences Institute Grant, 2012 o Research Project: “Effect of obesity on mitochondrial biogenesis during skeletal muscle regeneration.” Role: Principal Investigator (Funded: $25,400)

American Biosciences Institute Grant, 2012 o Research Project: “Defining the role of leucine in energy metabolism for prevention of obesity and type 2 diabetes.” Role: Co-Principal Investigator: (Funded: $49,749)

American Biosciences Institute Grant, 2012 o Research Project: “Heat shock proteins, AMPK and cell bioenergetics in muscle, liver, and fibroblast cells.” Role: Co-Principal Investigator: (Funded: $43,790)

University of Evansville ARSAF Grant, 2010-2011 Research Project: “The Effect of Interleukin-6 Deficiency on Extracellular Matrix Remodeling During Recovery from Myotoxin-Induced Injury.” Principal Investigator: Tyrone A. Washington (FUNDED: $6,790)

University of Evansville ARTS Grant, 2010-2011 o Research Project: “The Effect of Interleukin-6 Deficiency on Cell Cycle Regulation During Recovery from Myotoxin-Induced Injury.” Principal Investigator: Tyrone A. Washington (FUNDED: $2,150)

South Carolina/NASA Space Grant, 2005-2006 o Research Project: “Estrogen loss and skeletal muscle atrophy.” Student: Tyrone Washington; Principal Investigator: James A. Carson and Larry L. Lowe (FUNDED: $18,000)

University of South Carolina Graduate Research Fellow, 2002-2006 (Award: $7500/year)

South Carolina/NASA Space Grant, 2002-2003 o Research Project: “Lactate Dehydrogenase activity and mRNA abundance in atrophying and hypertrophying muscle.” Student: Tyrone A. Washington; Principal Investigator: James A. Carson and Larry L. Lowe (FUNDED: $10,250).

Outstanding Oral Communications Presentation, 2007 Midwestern American College of Sports Medicine.

Beta Kappa Chi Scientific Honor Society / National Institute of Science Brookhaven Semester Program– Graduate Student Oral Presentation research Award, 2002 o Submission titled “Decreased lactate dehydogenase activity at the onset of functional overload in rat plantaris muscle”. ($500) Student: Tyrone Washington, Principal Investigator: J.A. Carson